Allosteric Inhibition of Anti-Apoptotic MCL-1

MCL-1 is an anti-apoptotic BCL-2 family protein that has emerged as a major pathogenic factor in human cancer. Like BCL-2, MCL-1 bears a surface groove whose function is to sequester the BH3 killer domains of pro-apoptotic BCL-2 family members, a mechanism harnessed by cancer cells to establish form...

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Publicado en:Nat Struct Mol Biol
Autores principales: Lee, Susan, Wales, Thomas E., Escudero, Silvia, Cohen, Daniel T., Luccarelli, James, Gallagher, Catherine, Cohen, Nicole A., Huhn, Annissa J., Bird, Gregory H., Engen, John R., Walensky, Loren D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900187/
https://ncbi.nlm.nih.gov/pubmed/27159560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3223
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