Allosteric Sensitization of Pro-Apoptotic BAX

BAX is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation-prone protein. Here, we overcame prior challen...

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Bibliografiska uppgifter
I publikationen:Nat Chem Biol
Huvudupphovsmän: Pritz, Jonathan R., Wachter, Franziska, Lee, Susan, Luccarelli, James, Wales, Thomas E., Cohen, Daniel T., Coote, Paul W., Heffron, Gregory J., Engen, John R., Massefski, Walter, Walensky, Loren D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675120/
https://ncbi.nlm.nih.gov/pubmed/28692068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2433
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