Allosteric Sensitization of Pro-Apoptotic BAX

BAX is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation-prone protein. Here, we overcame prior challen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Chem Biol
Prif Awduron: Pritz, Jonathan R., Wachter, Franziska, Lee, Susan, Luccarelli, James, Wales, Thomas E., Cohen, Daniel T., Coote, Paul W., Heffron, Gregory J., Engen, John R., Massefski, Walter, Walensky, Loren D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675120/
https://ncbi.nlm.nih.gov/pubmed/28692068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2433
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg