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Allosteric Sensitization of Pro-Apoptotic BAX
BAX is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation-prone protein. Here, we overcame prior challen...
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| Publié dans: | Nat Chem Biol |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5675120/ https://ncbi.nlm.nih.gov/pubmed/28692068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2433 |
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