BH3-Triggered Structural Reorganization Drives the Activation of Pro-apoptotic BAX

BAX is a pro-apoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress. Having recently identified the elusive trigger site for direct BAX activation, we now delineate by NMR and biochemical methods the essential allosteric co...

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Detaylı Bibliyografya
Asıl Yazarlar: Gavathiotis, Evripidis, Reyna, Denis E., Davis, Marguerite L., Bird, Gregory H., Walensky, Loren D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050027/
https://ncbi.nlm.nih.gov/pubmed/21070973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.10.019
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