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BH3-Triggered Structural Reorganization Drives the Activation of Pro-apoptotic BAX
BAX is a pro-apoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress. Having recently identified the elusive trigger site for direct BAX activation, we now delineate by NMR and biochemical methods the essential allosteric co...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050027/ https://ncbi.nlm.nih.gov/pubmed/21070973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.10.019 |
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