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BH3-Triggered Structural Reorganization Drives the Activation of Pro-apoptotic BAX

BAX is a pro-apoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress. Having recently identified the elusive trigger site for direct BAX activation, we now delineate by NMR and biochemical methods the essential allosteric co...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gavathiotis, Evripidis, Reyna, Denis E., Davis, Marguerite L., Bird, Gregory H., Walensky, Loren D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050027/
https://ncbi.nlm.nih.gov/pubmed/21070973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.10.019
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