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Design of Stapled Antimicrobial Peptides that Overcome Antibiotic Resistance and In Vivo Toxicity
The clinical translation of cationic alpha-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation, and in vivo toxicity from non-specific membrane lysis. Although analyses of hydrophobic content and charge distribution have informed the design of s...
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| Publicado no: | Nat Biotechnol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7437984/ https://ncbi.nlm.nih.gov/pubmed/31427820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0222-z |
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