Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

Mechanisms of resistance to cancer immunotherapy remain poorly understood. Lymphocyte Activation Gene-3 (LAG3) signaling is regulated by A Disintegrin And Metalloprotease-10 (ADAM10) and ADAM17-mediated cell surface shedding. Here we show that mice expressing a metalloprotease-resistant, non-cleavab...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Andrews, Lawrence P., Somasundaram, Ashwin, Moskovitz, Jessica M., Szymczak-Workman, Andrea L., Liu, Chang, Cillo, Anthony R., Lin, Huang, Normolle, Daniel P., Moynihan, Kelly D., Taniuchi, Ichiro, Irvine, Darrell J., Kirkwood, John M., Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901539/
https://ncbi.nlm.nih.gov/pubmed/32680952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abc2728
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados