Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

Mechanisms of resistance to cancer immunotherapy remain poorly understood. Lymphocyte Activation Gene-3 (LAG3) signaling is regulated by A Disintegrin And Metalloprotease-10 (ADAM10) and ADAM17-mediated cell surface shedding. Here we show that mice expressing a metalloprotease-resistant, non-cleavab...

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Veröffentlicht in:Sci Immunol
Hauptverfasser: Andrews, Lawrence P., Somasundaram, Ashwin, Moskovitz, Jessica M., Szymczak-Workman, Andrea L., Liu, Chang, Cillo, Anthony R., Lin, Huang, Normolle, Daniel P., Moynihan, Kelly D., Taniuchi, Ichiro, Irvine, Darrell J., Kirkwood, John M., Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901539/
https://ncbi.nlm.nih.gov/pubmed/32680952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abc2728
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