Neuropilin-1 is a T cell memory checkpoint limiting long-term anti-tumor immunity

Robust CD8(+) T cell memory is essential for long-term protective immunity, but is often compromised in cancer where T cell exhaustion leads to loss of memory precursors. Immunotherapy via checkpoint blockade may not effectively reverse this defect, potentially underlying disease relapse. Here we re...

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Pubblicato in:Nat Immunol
Autori principali: Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., Wherry, E. John, Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442600/
https://ncbi.nlm.nih.gov/pubmed/32661362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0733-2
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