Neuropilin-1 is a T cell memory checkpoint limiting long-term anti-tumor immunity

Robust CD8(+) T cell memory is essential for long-term protective immunity, but is often compromised in cancer where T cell exhaustion leads to loss of memory precursors. Immunotherapy via checkpoint blockade may not effectively reverse this defect, potentially underlying disease relapse. Here we re...

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Publicat a:Nat Immunol
Autors principals: Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., Wherry, E. John, Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442600/
https://ncbi.nlm.nih.gov/pubmed/32661362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0733-2
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