Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator

Super-enhancers (SEs) mediate high transcription levels of target genes. Previous studies have shown that SEs recruit transcription complexes and generate enhancer RNAs (eRNAs). We characterized transcription at the human and murine β-globin locus control region (LCR) SE. We found that the human LCR...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Gurumurthy, Aishwarya, Yu, David T, Stees, Jared R, Chamales, Pamela, Gavrilova, Ekaterina, Wassel, Paul, Li, Lu, Stribling, Daniel, Chen, Jinyang, Brackett, Marissa, Ishov, Alexander M, Xie, Mingyi, Bungert, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897481/
https://ncbi.nlm.nih.gov/pubmed/33476375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab002
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