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Phase separation and transcription regulation: Are super-enhancers and locus control regions primary sites of transcription complex assembly?

We propose that the multiple enhancer elements associated with locus control regions and super-enhancers recruit RNA polymerase II and efficiently assemble elongation competent transcription complexes that are transferred to target genes by transcription termination and transient looping mechanisms....

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Detalles Bibliográficos
Publicado en:Bioessays
Main Authors: Gurumurthy, Aishwarya, Shen, Yong, Gunn, Eliot, Bungert, Jörg
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484441/
https://ncbi.nlm.nih.gov/pubmed/30500078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201800164
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