ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation

Release of paused RNA polymerase II (Pol II) requires incorporation of the positive transcription elongation factor b (P-TEFb) into the super elongation complex (SEC), thus resulting in rapid yet synchronous transcriptional activation. However, the mechanism underlying dynamic transition of P-TEFb f...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Guo, Chenghao, Che, Zhuanzhuan, Yue, Junjie, Xie, Peng, Hao, Shaohua, Xie, Wei, Luo, Zhuojuan, Lin, Chengqi
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2020
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112754/
https://ncbi.nlm.nih.gov/pubmed/32270036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay4858
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