ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation

Release of paused RNA polymerase II (Pol II) requires incorporation of the positive transcription elongation factor b (P-TEFb) into the super elongation complex (SEC), thus resulting in rapid yet synchronous transcriptional activation. However, the mechanism underlying dynamic transition of P-TEFb f...

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Pubblicato in:Sci Adv
Autori principali: Guo, Chenghao, Che, Zhuanzhuan, Yue, Junjie, Xie, Peng, Hao, Shaohua, Xie, Wei, Luo, Zhuojuan, Lin, Chengqi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112754/
https://ncbi.nlm.nih.gov/pubmed/32270036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay4858
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