JNK2, A Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca(2+)]SR Leak-Load Relationship

RATIONALE: We recently discovered pivotal contributions of stress kinase JNK2 in increased risk of atrial fibrillation (AF) through enhanced diastolic sarcoplasmic reticulum (SR) Ca(2+) leak via ryanodine receptors (RyR2). However, the role of JNK2 in the function of the SR Ca(2+)-ATPase (SERCA2), e...

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Detalles Bibliográficos
Publicado en:Circ Res
Main Authors: Yan, Jiajie, Bare, Dan J, DeSantiago, Jaime, Zhao, Weiwei, Mei, Yiming, Chen, Zhenhui, Ginsburg, Kenneth, Solaro, R John, Wolska, Beata M, Bers, Donald M, Chen, S.R. Wayne, Ai, Xun
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897290/
https://ncbi.nlm.nih.gov/pubmed/33334123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.318409
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