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JNK2, A Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca(2+)]SR Leak-Load Relationship
RATIONALE: We recently discovered pivotal contributions of stress kinase JNK2 in increased risk of atrial fibrillation (AF) through enhanced diastolic sarcoplasmic reticulum (SR) Ca(2+) leak via ryanodine receptors (RyR2). However, the role of JNK2 in the function of the SR Ca(2+)-ATPase (SERCA2), e...
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| Publicado no: | Circ Res |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7897290/ https://ncbi.nlm.nih.gov/pubmed/33334123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.318409 |
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