SERCA2a Gene Transfer Decreases SR Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure

BACKGROUND: Sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) gene therapy improves mechanical function in heart failure, and is under evaluation in a clinical trial. A critical question is whether SERCA2a gene therapy predisposes to increased sarcoplasmic reticulum calcium (SR Ca(2+)) leak, cellul...

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Main Authors: Lyon, Alexander R., Bannister, Mark L., Collins, Tom, Pearce, Emma, Sepehripour, Amir H., Dubb, Sukhpreet S., Garcia, Edwin, O'Gara, Peter, Liang, Lifan, Kohlbrenner, Erik, Hajjar, Roger J., Peters, Nicholas S., Poole-Wilson, Philip A., Macleod, Ken T., Harding, Sian E.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119354/
https://ncbi.nlm.nih.gov/pubmed/21406682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.110.961615
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