Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) results in right ventricular (RV) failure, electro-mechanical dysfunction and heightened risk of sudden cardiac death (SCD), although exact mechanisms and predisposing factors remain unclear. Because impaired chronotropic response to exercise is a st...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Strauss, Benjamin, Sassi, Yassine, Bueno-Beti, Carlos, Ilkan, Zeki, Raad, Nour, Cacheux, Marine, Bisserier, Malik, Turnbull, Irene C., Kohlbrenner, Erik, Hajjar, Roger J, Hadri, Lahouaria, Akar, Fadi G
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561115/
https://ncbi.nlm.nih.gov/pubmed/30502350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.11.017
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