Cardiomyocyte-Specific STIM1 (Stromal Interaction Molecule 1) Depletion in the Adult Heart Promotes the Development of Arrhythmogenic Discordant Alternans

BACKGROUND: STIM1 (stromal interaction molecule 1) is a calcium (Ca(2+)) sensor that regulates cardiac hypertrophy by triggering store-operated Ca(2+) entry. Because STIM1 binding to phospholamban increases sarcoplasmic reticulum Ca(2+) load independent of store-operated Ca(2+) entry, we hypothesize...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Cacheux, Marine, Strauss, Benjamin, Raad, Nour, Ilkan, Zeki, Hu, Jun, Benard, Ludovic, Feske, Stefan, Hulot, Jean-Sebastien, Akar, Fadi G.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867678/
https://ncbi.nlm.nih.gov/pubmed/31726860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.119.007382
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