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NS5806 Induces Electromechanically Discordant Alternans and Arrhythmogenic Voltage-Calcium Dynamics in the Isolated Intact Rabbit Heart
Background: NS5806 activates the transient outward potassium current I(to), and has been claimed to reproduce Brugada Syndrome (BrS) in ventricular wedge preparations. I(to) modulates excitation-contraction coupling, which is critical in alternans dynamics. We explored NS5806-arrhythmogenic effects...
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| Publicado no: | Front Physiol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6933003/ https://ncbi.nlm.nih.gov/pubmed/31920713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01509 |
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