NS5806 Induces Electromechanically Discordant Alternans and Arrhythmogenic Voltage-Calcium Dynamics in the Isolated Intact Rabbit Heart

Background: NS5806 activates the transient outward potassium current I(to), and has been claimed to reproduce Brugada Syndrome (BrS) in ventricular wedge preparations. I(to) modulates excitation-contraction coupling, which is critical in alternans dynamics. We explored NS5806-arrhythmogenic effects...

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Udgivet i:Front Physiol
Main Authors: Wang, Sufen, Rodríguez-Mañero, Moisés, Ibarra-Cortez, Sergio H., Kreidieh, Bahij, Valderrábano, Laura, Hemam, Majd, Tavares, Liliana, Blanco, Elvin, Valderrábano, Miguel
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933003/
https://ncbi.nlm.nih.gov/pubmed/31920713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01509
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