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Epac2 Mediates Cardiac β1-Adrenergic Dependent SR Ca(2+) Leak and Arrhythmia
BACKGROUND: β-adrenergic receptor (β-AR) activation can provoke cardiac arrhythmias mediated by cAMP-dependent alterations of Ca(2+) signaling. However cAMP can activate both PKA and an Exchange protein directly activated by cAMP (Epac) but their functional interaction is unclear. In heart selective...
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| Glavni autori: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690126/ https://ncbi.nlm.nih.gov/pubmed/23363625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.12.148619 |
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