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Targeting Pathological Leak of Ryanodine Receptors: Preclinical Progress and the Potential Impact on Treatments for Cardiac Arrhythmias and Heart Failure
INTRODUCTION: Type-2 ryanodine receptor (RyR2) located on the sarcoplasmic reticulum initiate systolic Ca(2+) transients within cardiomyocytes. Proper functioning of RyR2 is therefore crucial to the timing and force generated by cardiomyocytes within a healthy heart. Improper intracellular Ca(2+) ha...
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| Veröffentlicht in: | Expert Opin Ther Targets |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6956596/ https://ncbi.nlm.nih.gov/pubmed/31869254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14728222.2020.1708326 |
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