Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

Catecholaminergic polymorphic ventricular tachycardia is a form of exercise-induced sudden cardiac death that has been linked to mutations in the cardiac Ca(2+) release channel/ryanodine receptor (RyR2) located on the sarcoplasmic reticulum (SR). We have shown that catecholaminergic polymorphic vent...

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Detalhes bibliográficos
Main Authors: Lehnart, Stephan E., Terrenoire, Cecile, Reiken, Steven, Wehrens, Xander H. T., Song, Long-Sheng, Tillman, Erik J., Mancarella, Salvatore, Coromilas, James, Lederer, W. J., Kass, Robert S., Marks, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472543/
https://ncbi.nlm.nih.gov/pubmed/16672364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602133103
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