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Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging
Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents were oxidized, cysteine-nitr...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690519/ https://ncbi.nlm.nih.gov/pubmed/21803290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.05.014 |
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