Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents were oxidized, cysteine-nitr...

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Main Authors: Andersson, Daniel C., Betzenhauser, Mathew J., Reiken, Steven, Meli, Albano C., Umanskaya, Alisa, Xie, Wenjun, Shiomi, Takayuki, Zalk, Ran, Lacampagne, Alain, Marks, Andrew R.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690519/
https://ncbi.nlm.nih.gov/pubmed/21803290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.05.014
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