Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation

Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Matecki, Stefan, Dridi, Haikel, Jung, Boris, Saint, Nathalie, Reiken, Steven R., Scheuermann, Valérie, Mrozek, Ségolène, Santulli, Gaetano, Umanskaya, Alisa, Petrof, Basil J., Jaber, Samir, Marks, Andrew R., Lacampagne, Alain
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987795/
https://ncbi.nlm.nih.gov/pubmed/27457930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609707113
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