Hypernitrosylated ryanodine receptor/calcium release channels are leaky in dystrophic muscle

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness and early death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large dystrophin glycoprotein complex (DGC) leading to pathologic calcium (Ca(2+))-dependent signals that damage muscl...

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Bibliografiske detaljer
Main Authors: Bellinger, Andrew M., Reiken, Steven, Carlson, Christian, Mongillo, Marco, Liu, Xiaoping, Rothman, Lisa, Matecki, Stefan, Lacampagne, Alain, Marks, Andrew R.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910579/
https://ncbi.nlm.nih.gov/pubmed/19198614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1916
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