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Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacity
During exercise, defects in calcium (Ca(2+)) release have been proposed to impair muscle function. Here, we show that during exercise in mice and humans, the major Ca(2+) release channel required for excitation–contraction coupling (ECC) in skeletal muscle, the ryanodine receptor (RyR1), is progress...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2538898/ https://ncbi.nlm.nih.gov/pubmed/18268335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711074105 |
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