Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias

Phosphodiesterases (PDEs) regulate the local concentration of 3′,5′ cyclic adenosine monophosphate (cAMP) within cells. cAMP activates the cAMP-dependent protein kinase (PKA). In patients, PDE inhibitors have been linked to heart failure and cardiac arrhythmias, although the mechanisms are not under...

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Main Authors: Lehnart, Stephan E., Wehrens, Xander H.T., Reiken, Steven, Warrier, Sunita, Belevych, Andriy E., Harvey, Robert D., Richter, Wito, Jin, S.-L. Catherine, Conti, Marco, Marks, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901878/
https://ncbi.nlm.nih.gov/pubmed/16213210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2005.07.030
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