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Targeting Pathological Leak of Ryanodine Receptors: Preclinical Progress and the Potential Impact on Treatments for Cardiac Arrhythmias and Heart Failure

INTRODUCTION: Type-2 ryanodine receptor (RyR2) located on the sarcoplasmic reticulum initiate systolic Ca(2+) transients within cardiomyocytes. Proper functioning of RyR2 is therefore crucial to the timing and force generated by cardiomyocytes within a healthy heart. Improper intracellular Ca(2+) ha...

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Detalhes bibliográficos
Publicado no:Expert Opin Ther Targets
Main Authors: Connell, Patrick, Word, Tarah A., Wehrens, Xander H.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956596/
https://ncbi.nlm.nih.gov/pubmed/31869254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14728222.2020.1708326
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