Epac2 Mediates Cardiac β1-Adrenergic Dependent SR Ca(2+) Leak and Arrhythmia

BACKGROUND: β-adrenergic receptor (β-AR) activation can provoke cardiac arrhythmias mediated by cAMP-dependent alterations of Ca(2+) signaling. However cAMP can activate both PKA and an Exchange protein directly activated by cAMP (Epac) but their functional interaction is unclear. In heart selective...

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Detaylı Bibliyografya
Asıl Yazarlar: Pereira, Laëtitia, Cheng, Hongqiang, Lao, Dieu Hung, Na, Li, van Oort, Ralph J., Brown, Joan Heller, Wehrens, Xander H.T., Chen, Ju, Bers, Donald M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690126/
https://ncbi.nlm.nih.gov/pubmed/23363625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.12.148619
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