SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway

AIMS: Impaired myocardial sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) activity is a hallmark of failing hearts, and SERCA2a gene therapy improves cardiac function in animals and patients with heart failure (HF). Deregulation of microRNAs has been demonstrated in HF pathophysiology. We studied...

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Detalhes bibliográficos
Main Authors: Kumarswamy, Regalla, Lyon, Alexander R., Volkmann, Ingo, Mills, Adam M., Bretthauer, Julia, Pahuja, Aanchal, Geers-Knörr, Cornelia, Kraft, Theresia, Hajjar, Roger J., Macleod, Kenneth T., Harding, Sian E., Thum, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Fasttrack Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341631/
https://ncbi.nlm.nih.gov/pubmed/22362515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehs043
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