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Structure of an activated DNA-PK and its implications for NHEJ
DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKIN) along with solenoid structures made of HEAT repeats. These kinases are activated in response to cellular stress signals, but the mechanisms...
में बचाया:
| में प्रकाशित: | Mol Cell |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7897279/ https://ncbi.nlm.nih.gov/pubmed/33385326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.015 |
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