Structure of an activated DNA-PK and its implications for NHEJ

DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKIN) along with solenoid structures made of HEAT repeats. These kinases are activated in response to cellular stress signals, but the mechanisms...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Chen, Xuemin, Xu, Xiang, Chen, Yun, Cheung, Joyce C., Wang, Huaibin, Jiang, Jiansen, de Val, Natalia, Fox, Tara, Gellert, Martin, Yang, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897279/
https://ncbi.nlm.nih.gov/pubmed/33385326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.015
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