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Structure of an activated DNA-PK and its implications for NHEJ
DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKIN) along with solenoid structures made of HEAT repeats. These kinases are activated in response to cellular stress signals, but the mechanisms...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7897279/ https://ncbi.nlm.nih.gov/pubmed/33385326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.015 |
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