Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth

Hedgehog (Hh) signaling plays a critical role in embryogenesis and tissue homeostasis, and its deregulation has been associated with tumor growth. The tumor suppressor SuFu inhibits Hh signaling by preventing the nuclear translocation of Gli and suppressing cell proliferation. Regulation of SuFu act...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Yan, Zhengwei, Cheng, Minzhang, Hu, Guohui, Wang, Yao, Zeng, Shaopeng, Huang, Aidi, Xu, Linlin, Liu, Yuan, Shi, Chao, Deng, Libin, Lu, Quqin, Rao, Hai, Lu, Hua, Chen, Ye-Guang, Luo, Shiwen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896051/
https://ncbi.nlm.nih.gov/pubmed/33608498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03487-0
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