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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

In vertebrates, Hedgehog (Hh) signaling initiated in primary cilia activates the membrane protein Smoothened (Smo) and leads to activation of Gli proteins, the transcriptional effectors of the pathway. In the absence of signaling, Gli proteins are inhibited by the cytoplasmic protein Suppressor of F...

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Autors principals: Tukachinsky, Hanna, Lopez, Lyle V., Salic, Adrian
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958481/
https://ncbi.nlm.nih.gov/pubmed/20956384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201004108
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