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Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog
The Hedgehog cell–cell signaling pathway is crucial for animal development, and its misregulation is implicated in numerous birth defects and cancers. In unstimulated cells, pathway activity is inhibited by the tumor suppressor membrane protein, Patched. Hedgehog signaling is triggered by the secret...
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| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2016
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5056095/ https://ncbi.nlm.nih.gov/pubmed/27647915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606719113 |
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