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Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog
The Hedgehog cell–cell signaling pathway is crucial for animal development, and its misregulation is implicated in numerous birth defects and cancers. In unstimulated cells, pathway activity is inhibited by the tumor suppressor membrane protein, Patched. Hedgehog signaling is triggered by the secret...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5056095/ https://ncbi.nlm.nih.gov/pubmed/27647915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606719113 |
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