Caricamento...
Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
The Hedgehog (Hh) pathway controls embryonic development and postnatal tissue maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh ligands relieves suppression of signaling cascades. Here, we report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylat...
Salvato in:
| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6534611/ https://ncbi.nlm.nih.gov/pubmed/31127104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10234-9 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|