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Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
The Hedgehog (Hh) pathway controls embryonic development and postnatal tissue maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh ligands relieves suppression of signaling cascades. Here, we report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylat...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6534611/ https://ncbi.nlm.nih.gov/pubmed/31127104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10234-9 |
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