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Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
The Hedgehog (Hh) pathway controls embryonic development and postnatal tissue maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh ligands relieves suppression of signaling cascades. Here, we report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylat...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6534611/ https://ncbi.nlm.nih.gov/pubmed/31127104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10234-9 |
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