The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

Hedgehog (HH) ligands, classical morphogens that pattern embryonic tissues in all animals, are covalently coupled to two lipids-- a palmitoyl group at the N-terminus and a cholesteroyl group at the C-terminus. While the palmitoyl group binds and inactivates Patched 1 (PTCH1), the main receptor for H...

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Publicado no:Nat Chem Biol
Main Authors: Rudolf, Amalie F., Kinnebrew, Maia, Kowatsch, Christiane, Ansell, T. Bertie, Omari, Kamel El, Bishop, Benjamin, Pardon, Els, Schwab, Rebekka A., Malinauskas, Tomas, Qian, Mingxing, Duman, Ramona, Covey, Douglas F., Steyaert, Jan, Wagner, Armin, Sansom, Mark S. P., Rohatgi, Rajat, Siebold, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764859/
https://ncbi.nlm.nih.gov/pubmed/31548691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0370-y
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