The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

Hedgehog (HH) ligands, classical morphogens that pattern embryonic tissues in all animals, are covalently coupled to two lipids-- a palmitoyl group at the N-terminus and a cholesteroyl group at the C-terminus. While the palmitoyl group binds and inactivates Patched 1 (PTCH1), the main receptor for H...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Rudolf, Amalie F., Kinnebrew, Maia, Kowatsch, Christiane, Ansell, T. Bertie, Omari, Kamel El, Bishop, Benjamin, Pardon, Els, Schwab, Rebekka A., Malinauskas, Tomas, Qian, Mingxing, Duman, Ramona, Covey, Douglas F., Steyaert, Jan, Wagner, Armin, Sansom, Mark S. P., Rohatgi, Rajat, Siebold, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764859/
https://ncbi.nlm.nih.gov/pubmed/31548691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0370-y
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