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G-protein coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog
The morphogen Sonic Hedgehog (SHH) patterns tissues during development by directing cell fates in a concentration-dependent manner. The SHH signal is transmitted across the membrane of target cells by the heptahelical transmembrane protein Smoothened (SMO), which activates the GLI family of transcri...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5828112/ https://ncbi.nlm.nih.gov/pubmed/29438014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao5749 |
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