A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection

Cancer cells display high levels of DNA damage and replication stress, vulnerabilities that could be exploited by drugs targeting DNA repair proteins. Human CtIP promotes homology-mediated repair of DNA double-strand breaks (DSBs) and protects stalled replication forks from nucleolytic degradation,...

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Vydáno v:Sci Adv
Hlavní autoři: Kuster, Anika, Mozaffari, Nour L., Wilkinson, Oliver J., Wojtaszek, Jessica L., Zurfluh, Christina, Przetocka, Sara, Zyla, Dawid, von Aesch, Christine, Dillingham, Mark S., Williams, R. Scott, Sartori, Alessandro A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895427/
https://ncbi.nlm.nih.gov/pubmed/33608267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc6381
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