A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection

Cancer cells display high levels of DNA damage and replication stress, vulnerabilities that could be exploited by drugs targeting DNA repair proteins. Human CtIP promotes homology-mediated repair of DNA double-strand breaks (DSBs) and protects stalled replication forks from nucleolytic degradation,...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Adv
Asıl Yazarlar: Kuster, Anika, Mozaffari, Nour L., Wilkinson, Oliver J., Wojtaszek, Jessica L., Zurfluh, Christina, Przetocka, Sara, Zyla, Dawid, von Aesch, Christine, Dillingham, Mark S., Williams, R. Scott, Sartori, Alessandro A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2021
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895427/
https://ncbi.nlm.nih.gov/pubmed/33608267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc6381
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller