CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

CtIP is involved in the resection of broken DNA during the S and G2 phases of the cell cycle for repair by recombination. Acting with the MRN complex, it plays a particularly important role in handling complex DNA end structures by localised nucleolytic processing of DNA termini in preparation for l...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wilkinson, Oliver J, Martín-González, Alejandro, Kang, Haejoo, Northall, Sarah J, Wigley, Dale B, Moreno-Herrero, Fernando, Dillingham, Mark Simon
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344080/
https://ncbi.nlm.nih.gov/pubmed/30601117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42129
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