Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

Human CtIP is a decisive factor in DNA double-strand break repair pathway choice by enabling DNA-end resection, the first step that differentiates homologous recombination (HR) from non-homologous end-joining (NHEJ). To coordinate appropriate and timely execution of DNA-end resection, CtIP function...

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Publicat a:Nat Commun
Autors principals: Ferretti, Lorenza P., Himmels, Sarah-Felicitas, Trenner, Anika, Walker, Christina, von Aesch, Christine, Eggenschwiler, Aline, Murina, Olga, Enchev, Radoslav I., Peter, Matthias, Freire, Raimundo, Porro, Antonio, Sartori, Alessandro A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007465/
https://ncbi.nlm.nih.gov/pubmed/27561354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12628
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