DNA end resection by CtIP and exonuclease 1 prevents genomic instability

End resection of DNA—which is essential for the repair of DNA double-strand breaks (DSBs) by homologous recombination—relies first on the partnership between MRE11–RAD50–NBS1 (MRN) and CtIP, followed by a processive step involving helicases and exonucleases such as exonuclease 1 (EXO1). In this stud...

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Detalhes bibliográficos
Main Authors: Eid, Wassim, Steger, Martin, El-Shemerly, Mahmoud, Ferretti, Lorenza P, Peña-Diaz, Javier, König, Christiane, Valtorta, Emanuele, Sartori, Alessandro A, Ferrari, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999859/
https://ncbi.nlm.nih.gov/pubmed/21052091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.157
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