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CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation
To prevent accumulation of mutations, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homology-directed repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in activation of ATR (ataxia telangiectasia m...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384414/ https://ncbi.nlm.nih.gov/pubmed/22733999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201111065 |
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