CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation

To prevent accumulation of mutations, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homology-directed repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in activation of ATR (ataxia telangiectasia m...

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Detaylı Bibliyografya
Asıl Yazarlar: Kousholt, Arne Nedergaard, Fugger, Kasper, Hoffmann, Saskia, Larsen, Brian D., Menzel, Tobias, Sartori, Alessandro A., Sørensen, Claus Storgaard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2012
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384414/
https://ncbi.nlm.nih.gov/pubmed/22733999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201111065
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