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And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance
To prevent genomic instability, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homologous recombination repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in activation of CHK1 kinase to induce the c...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389581/ https://ncbi.nlm.nih.gov/pubmed/27940552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1212 |
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