And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance

To prevent genomic instability, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homologous recombination repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in activation of CHK1 kinase to induce the c...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Chen, Yali, Liu, Hailong, Zhang, Haoxing, Sun, Changqing, Hu, Zhaohua, Tian, Qingsong, Peng, Changmin, Jiang, Pei, Hua, Hui, Li, Xinzhi, Pei, Huadong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389581/
https://ncbi.nlm.nih.gov/pubmed/27940552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1212
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