Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression

Increased lipid synthesis is a key characteristic of many cancers that is critical for cancer progression. ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, is frequently overexpressed or activated in cancer to promote lipid synthesis and tumor progression. Cullin3 (CUL3), a core protein f...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Zhang, Cen, Liu, Juan, Huang, Grace, Zhao, Yuhan, Yue, Xuetian, Wu, Hao, Li, Jun, Zhu, Junlan, Shen, Zhiyuan, Haffty, Bruce G., Hu, Wenwei, Feng, Zhaohui
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066239/
https://ncbi.nlm.nih.gov/pubmed/27664236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.283283.116
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