Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead

[Image: see text] Covalent inhibitors of wild-type HIV-1 reverse transcriptase (CRTIs) are reported. Three compounds derived from catechol diether non-nucleoside inhibitors (NNRTIs) with addition of a fluorosulfate warhead are demonstrated to covalently modify Tyr181 of HIV-RT. X-ray crystal structu...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Ippolito, Joseph A., Niu, Haichan, Bertoletti, Nicole, Carter, Zachary J., Jin, Shengyan, Spasov, Krasimir A., Cisneros, José A., Valhondo, Margarita, Cutrona, Kara J., Anderson, Karen S., Jorgensen, William L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2021
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883463/
https://ncbi.nlm.nih.gov/pubmed/33603971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00612
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