Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography

Development of resistance remains a major challenge for drugs to treat HIV-1 infections, including those targeting the essential viral polymerase, HIV-1 reverse transcriptase (RT). Resistance associated with the Tyr181Cys mutation in HIV-1 RT has been a key roadblock in the discovery of nonnucleosid...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chan, Albert H., Lee, Won-Gil, Spasov, Krasimir A., Cisneros, José A., Kudalkar, Shalley N., Petrova, Zaritza O., Buckingham, Amanda B., Anderson, Karen S., Jorgensen, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594698/
https://ncbi.nlm.nih.gov/pubmed/28827354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711463114
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